Displaying items by tag: DNA methylation

Scientists have discovered that pancreatic cancer deactivates molecules within the HNF4A gene, leading to rapid growth and spread. This breakthrough offers hope for better treatments against this deadly disease, which kills nearly 9,000 Britons a year. Dr Maria Hatziapostolou of Nottingham Trent University emphasised the urgency of new treatments, noting that pancreatic cancer has the lowest survival rate among common cancers. The research, involving multiple universities, showed that pancreatic cancer uses DNA methylation to switch off HNF4A molecules, promoting tumour growth. This discovery could pave the way for more effective treatment options, which are badly needed because most pancreatic cancers are diagnosed at a late stage when they are no longer operable. This research could significantly impact future treatment for a disease with notoriously poor survival rates.