President Biden marked 100 days in office with a speech that put into focus his domestic agenda, the most dramatic shift in federal economic and social welfare policies since Ronald Reagan forty years ago. Reagan’s philosophy resulted in decades-long squeezes on domestic spending and tax policies that benefit the wealthiest. If Biden gets his way Reagan’s policies will be replaced by ones directly addressing long-standing economic, racial and gender inequities. His speech reflected his presidency to date, appealing for bold action by a leader whose demeanour is opposite to that of Donald Trump. Biden believes there is an urgent need to act, an opportunity to do so, but limited time to get it done. He said the nation needs ‘a once-in-generation investment in families and children.’ But because of the Democrats’ narrow majorities and a nation still divided over the president’s performance, Biden’s agenda represents a political gamble.